PENINGKATAN KELARUTAN DAN LAJU DISOLUSI GLIMEPIRID MELALUI METODE KOKRISTALISASI

Authors

  • Fitrianti Darusman

Keywords:

glimepirid, kokristalisasi, eutektik, kelarutan dan laju disolusi

Abstract

Telah dilakukan kokristalisasi glimepirid (GMP) dengan asam oksalat (AO) menggunakan metode penggilingan dan pelarutan (menggunakan pelarut aseton). Diagram fase sistem biner GMP-AO digunakan untuk identifikasi awal pembentukan interaksi antar kedua komponen serta ditegaskan kembali dengan analisis mikroskopik menggunakan alat pemanas (hot stage) yang dihubungkan dengan mikroskop polarisasi. Padatan hasil kokristalisasi dikarakterisasi dengan metode analisis termal (Differential Scanning Calorymetry), difraktometri sinar-X serbuk (Powder X-Ray Diffraction), spektrofotometri inframerah (Fourier Transform-Infra Red) dan mikroskopi (Scanning Electron Microscope). Hasil identifikasi dan karakterisasi menunjukkan interaksi eutektik antara kedua fase kristalin GMP-AO dalam keadaan padat pada perbandingan molar 3:7, dengan titik eutektik pada temperatur 128,7°C. Selanjutnya, uji kelarutan dan laju disolusinya menggunakan media dapar fosfat pH 7,4. Kelarutan dan laju disolusi GMP hasil kokristalisasi meningkat dibandingkan dengan campuran fisika dan senyawa tunggalnya.

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References

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Published

2017-03-29

How to Cite

Darusman, F. (2017). PENINGKATAN KELARUTAN DAN LAJU DISOLUSI GLIMEPIRID MELALUI METODE KOKRISTALISASI. JURNAL FARMASI GALENIKA, 3(2), 47–54. Retrieved from https://journal.bku.ac.id/jfg/index.php/jfg/article/view/61

Issue

Vol. 3 No. 2 (2016): Jurnal Farmasi Galenika Volume 3 No. 2, 2016

Section

Artikel

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