Development Of Hand Antiseptic Gel Containing Lemon Essential Oil Using Gel Microemulsion Method

Authors

  • Patihul Husni Departemen Farmasetika dan Teknologi Farmasi, Fakultas Farmasi, Universitas Padjadjaran, Indonesia
  • Riska Cahya Lestari Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Al-Ghifari, Indonesia
  • Kusdi Hartono Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Al-Ghifari, Indonesia

DOI:

https://doi.org/10.70410/jfg.v11i2.342

Keywords:

Gel, Antiseptic, Essential Oil, Lemon (Citrus limon (L) Burm. F), Microemulsion

Abstract

Hand antiseptic gel preparation is a product that is widely used to protect the body from the entry of bacteria through the hands because of its practical use. Lemon peel (Citrus limon (L) Burm. F) contains essential oils that can inhibit the growth of bacteria so it can be used as a natural antiseptic. This research is aimed at obtaining the best formula preparation of hand antiseptic gel containing lemon essential oil (Citrus lemon (L) Burm. F). The microemulsion formula of lemon essential oil is optimized by making variations in the concentration of surfactant (Tween 80) and cosurfactant (propyleneglycol dan glycerin) which is then formulated into gel dosage form by using a variation in the concentration of the gelling agent. The preparation of the gel carried out a physical stability test that included organoleptic testing, homogeneity, pH, and viscosity. The optimization result of the best microemulsion formula is a formula with a Tween 80 as a surfactant and propylene glycol as a cosurfactant. Hand antiseptic gel preparation containing lemon essential oil (Citrus limon (L) Burm. F) with formula F2 is the best preparation because it is more stable according to the physical stability test of the preparation.

Downloads

Download data is not yet available.

References

Alhalwani, A., Husain, A., Saemaldahar, A., Makhdoum, F., Alhakami, M., Ashi, R., Wali, R., Alsharif, S., Khan, M. A. & Jastaniah, N. 2024. The impact of alcohol hand sanitizer use on skin health between healthcare worker: Cross?sectional study. Skin Research and Technology, 30, e13527.
Astuti, D. P., Husni, P. & Hartono, K. 2017. Formulasi dan uji stabilitas fisik sediaan gel antiseptik tangan minyak atsiri bunga lavender (Lavandula angustifolia Miller). Farmaka, 15, 176-184.
Bhatt, S., Patel, A., Kesselman, M. M., Demory, M. L. & Beckler, M. D. 2024. Hand Sanitizer: Stopping the Spread of Infection at a Cost. Cureus, 16.
Bourgou, S., Rahali, F. Z., Ourghemmi, I. & Saïdani Tounsi, M. 2012. Changes of peel essential oil composition of four Tunisian citrus during fruit maturation. The Scientific World Journal, 2012, 528593.
Chen, H., Lee, P., Chen, C., Huang, S., Huang, B., Dai, F., Chau, C., Chen, C. & Lin, Y. 2022. Moisture retention of glycerin solutions with various concentrations: a comparative study. Scientific Reports, 12, 10232.
Dewanti, A. P. & Azzahra, F. 2020. Uji karakteristik sediaan gel ekstrak etanol daun pandan (Pandanus amaryllifolius Roxb.) dengan basis hydroxy propyl methyl cellulose (HPMC). Afamedis, 1, 31-41.
Grampurohit, N., Ravikumar, P. & Mallya, R. 2011. Microemulsions for topical use–a review. Ind J Pharm Edu Res, 45, 100-107.
Ibrahim, F. M., Shalaby, E. S., El-Liethy, M. A., Abd-Elmaksoud, S., Mohammed, R. S., Shalaby, S. I., Rodrigues, C. V., Pintado, M. & Habbasha, E. S. E. 2024. Formulation and Characterization of Non-Toxic, Antimicrobial, and Alcohol-Free Hand Sanitizer Nanoemulgel Based on Lemon Peel Extract. Cosmetics, 11, 59.
Indriaty, S., Senja, R. Y., Firmansyah, D., Hidayati, N. R., Karlina, N., Zam, M. Y. Z. & Ramadhani, D. A. 2024. Antibacterial activity test of tea tree and lemon oil combination and its formulation in cream preparation. Medical Sains: Jurnal Ilmiah Kefarmasian, 9, 591-598.
Larasati, D., Putri, L. S. A., Daryanti, E. P., Arviani, A. & Najmah, N. 2024. Analisis Fitokimia dan Karakterisasi Masker Gel Peel-Off Ekstrak Etanol Daun Murbei (Morus alba L.). Jurnal Mandala Pharmacon Indonesia, 10, 328-337.
Latifah, N. & Fatmasari, E. 2024. Formulasi sediaan masker gel peel off dari ekstrak kulit buah pisang ambon lumut (Musa acuminata colla) sebagai antioksidan. Jurnal Insan Farmasi Indonesia, 7, 141-153.
Loden, M. & Alander, J. 2022. Hydrating substances. Handbook of cosmetic science and technology. CRC Press.
Nayayanan, K. S. 2018. Macro-and microemulsion technology and trends. Pesticide Formulation and Adjuvant Technology. CRC Press.
Pitaloka, S., Audina, M. & Aryzki, S. 2024. Pengaruh Na. CMC Terhadap Uji Stabilitas Sediaan Gel Ekstrak Etanol Bunga Rosella (Hibiscus Sabdariffa L.) Sebagai Anti Aging. Jurnal Dunia Ilmu Kesehatan (JURDIKES), 2, 48-56.
Saboorian-Jooybari, H. & Chen, Z. 2024. Critical review of microemulsion phase behavior models: benefits, research gaps, industrial challenges, and roadmap. Journal of Industrial Engineering Chemistry, 129, 1-23.
Safitri, F. I., Nawangsari, D. & Febrina, D. Overview: Application of carbopol 940 in gel. International Conference on Health and Medical Sciences (AHMS 2020), 2021. Atlantis Press, 80-84.
Saini, J. K., Nautiyal, U., Kumar, M., Singh, D. & Anwar, F. 2014. Microemulsions: A potential novel drug delivery system. International Journal of Pharmaceutical Medicinal Research, 2, 15-20.
Saini, S. M., Sagar, T. K., Dwivedi, Y. & Chandrashekharappa, S. 2024. Brief overview of surfactants, properties, classification, passivation, and role in chemistry. Surfactant Based Electroche, 3-20.
Salsabila, F. Z., Mahdan, R. K., Prihandini, G., Sudarman, R. & Yulistiani, F. 2022. Pengaruh suhu proses sokletasi dan volume pelarut n-heksana terhadap yield minyak atsiri jeruk lemon. Fluida, 15, 97-105.
Serasi, G. 2024. Evaluasi organoleptik, pengujian pH, dan potensi iritasi pada formulasi serum minyak kemiri (Aleuriteus moluccana) dan lidah buaya (Aloe vera). UNIVERSITAS NEGERI JAKARTA.
Susilowati, A. A., Marah, N. H. & Hayati, D. J. E. C. 2024. Formulasi dan uji aktivitas gel ekstrak daun cocor bebek (Bryophyllum pinnatum l.) terhadap luka bakar pada kelinci. Enfermeria Ciencia, 2, 22-33.
Tulsawani, R., Verma, K., Kohli, E., Sharma, P., Meena, Y. S., Amitabh, Ponmariappan, S., Kumar, P. & Maithani, R. 2024. Anti-microbial efficacy of a scientifically developed and standardized herbal-alcohol sanitizer. Archives of Microbiology, 206, 77.
Ulfah, M. & Munawaroh, R. 2014. Formulasi Sediaan Gel Antiseptik Tangan Minyak Atsiri Jeruk Lemon (Citrus Limon (L) Burm. F) Dengan Basis Karbopol Dan Aktivitas Antibakteri Terhadap Staphylococcus Aureus. Universitas Muhammadiyah Surakarta.
Usman, H., Rustini, R., Putri, L. E., Andrica, P. T. & Dwinatrana, K. 2024. Formulasi dan Uji Aktivitas Gel Hand Sanitizer Ekstrak Etanol Daging Buah Pala (Myristica Fragrans Houtt) dalam Menghambat Pertumbuhan Staphylococcus Aureus. Journal of Education and Culture, 4, 46-53.
Yuniarsih, N., Abriyani, E. & Shadrina, A. N. 2024. Formulasi, uji antioksidan dan antibakteri serum gel ekstrak kulit pisang kepok (Musa balbisiana) sebagai anti-acne. Jurnal Buana Farma, 4, 174-185.
Yusuf, A. L., Nugraha, D., Wahlanto, P., Indriastuti, M., Ismail, R. & Himah, F. A. 2022. Formulasi Dan Evaluasi Sediaan Gel Ekstrak Buah Pare (Momordica Charantia L.) Dengan Variasi Konsentrasi Carbopol 940. Pharmacy Genius, 1, 50-61.

Downloads

Published

2024-08-31

How to Cite

Husni, P., Cahya Lestari, R. ., & Hartono, K. (2024). Development Of Hand Antiseptic Gel Containing Lemon Essential Oil Using Gel Microemulsion Method. JURNAL FARMASI GALENIKA, 11(2), 108–122. https://doi.org/10.70410/jfg.v11i2.342

Citation Check