PEMBUATAN DAN KARAKTERISASI NATRIUM KURKUMIN

Authors

  • Wiwin Winingsih Sekolah Tinggi Farmasi Indonesia, Indonesia
  • Sri Gustini Husein Sekolah Tinggi Farmasi Indonesia, Indonesia
  • Melvia Sundalian Sekolah Tinggi Farmasi Indonesia, Indonesia

Keywords:

Kurkumin, Natrium Kurkumin, Kunyit, Curcuma domestica, Sintesis

Abstract

Kunyit (Curcuma domestica L.) termasuk family Zingiberaceae yang banyak terdapat di daerah tropis dan subtropis termasuk Indonesia. Kunyit telah banyak digunakan sebagai pewarna makanan, penambah rasa, dan obat tradisional. Peningkatan kelarutan kurkumin telah terbukti dapat meningkatkan bioavaibilitas dan juga efek farmakologinya. Pembuatan garam kurkumin larut air dilakukan dengan cara reaksi penggaraman dengan menggunakan natrium metoksida sehingga menghasilkan natrium kurkumin yang diharapkan dapat meningkat kelarutannya. Selain itu pada penelitian ini juga dilakukan karakterisasi garam kurkumin dengan spektrofotometri UV-Vis, FTIR, LC-MS, HPLC, dan KLT. Garam natrium Kurkumin dengan perbandingan molnatrium : kurkumin ( 1:1 ) dapat meningkatkan kelarutan kurkumin dalam air sebesar 620 kali. Hasil karakteristik garam kurkumindengan spektrofotometri menunjukann adanya perubahan  panjang gelombang maksimum (λ maks) dari 450 nm menjadi 350 nm. Garam natrium kurkumin menunjukkan adanya substitusi atom H oleh natrium yang mengakibatkan turunnya intensitas puncak pada daerah 3500-3000 cm-1. Hasil ujikarakteristik dengan KLT garam kurkumin dan kurkumin memiliki sedikit perbedaan nilai Rf. Garam natrium kurkumin dapat dibuat dengan mereaksikan natrium metoksida dan kurkumin.

Downloads

Download data is not yet available.

References

Anand, P.,Kunnumakkara, A.B., Newman, R.A. &Aggarwal,B.B. (2007).Bioavailability of curcumin: problems and promises.Mol.Pharm.4 (6): 807-18.
Anand, P.,Nair, H.B.,Sung, B.,Kunnumakkara, A.B., Yadav, V.R.,Tekmal, R.R. & Aggarwal B.B. (2010).Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem.Pharmacol.79: 330-338.
Enade P.I., Sri Utami, S., Andreas A.U. & Supardjana, A.M. (2004) Sintesis Senyawa Baru Berpotensi Anti Inflamasi: Garam Natrium Dari Pentagamavunon-0. Indonesian Journal of Chemistry; 4(3); 180-185.
Gupta,V.,Aseh A.,Rios,C.N., Aggarwal,B.B. &Mathur, A.B. (2009) Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy. Int.J.Nanomed.4 :115-22
Jasim,F. & Ali F. (1988) A novel and rapid method for the spectrofluorometric determination of curcumin in curcumin spices and flavors. Microchem.J.38 :106.
Keenan, K.W. (1992) Ilmu Kimia Untuk Universitas. Jakarta; Erlangga.
Khopkar, S.M. (2008)Konsep Dasar Kimia Analitik. Jakarta :UI Press.
Maiti K.,Mukherjee, K.,Gantait, A. &Saha,B.P. (2007), Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats.Int.J.Pharm.330 : 155-63.
Masuda,T.,Toi,Y.,Bando,H., Maekawa,T.,Takeda,Y. &Yamaguchi, H. (2002)Structural identification of new curcumin dimers and their contribution to the antioxidant mechanism of curcumin. J.Agric.Food Chem.50 (9): 2524-30
Mehta, K.,Pantazis,P.,McQueen, T. & Agarval, B.B. (1987)Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines. Anti-CancerDrugs.8 :470-81.
Nurfina,A.N.,Reksohadiprojo, M.S., Timmerman, H.,Jenie, U.A,Siguyanto, D.&Goot, H.V.D. (1997)Synthesis of some symmetrical curcumin derivatives and their antiinflammatory activity. Med.Chem.32:321-328.
Sreejayan, N., Priyadarsini, K.I., Devasagayam, T.P.A. & Rao, M.N.A. (1997) Inhibition of radiation induced lipid peroxidation by curcumin. Int. J. Pharmacol. 151: 125-129.
Sharma O.P.(1976) Antioxidant activity of curcumin and related compounds. Biochem.Pharmacol.25 (1)1811-2.
Wang, D., Veena, M.S., Stevenson, K., Tang, C., Ho, B., Suh, J.D., Duarte, V.M., Faull, K.F., Mehta, K., Srivatsan, E.S.& Wang MB. (2008) Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway.Clin.CancerRes.14: 6228
Venkatesan P. &Rao, M.N.(2000) Structure‐activity relationships for the inhibition of lipid peroxidation and the scavenging of free radicals by synthetic symmetrical curcumin analogues. The Journal of Pharmacy and Pharmacology. 52: 1123–1128
Zoran,M.M., et.al. (2015) Facile Synthesis of Water-Soluble Curcumin Nanocrystals. Journal of The Serbian Chemicals Society; 80(1); 63-72.

Downloads

Published

2018-05-28

How to Cite

Winingsih, W., Husein, S. G., & Sundalian, M. (2018). PEMBUATAN DAN KARAKTERISASI NATRIUM KURKUMIN. JURNAL FARMASI GALENIKA, 5(1), 22–29. Retrieved from https://journal.bku.ac.id/jfg/index.php/jfg/article/view/108

Issue

Vol. 5 No. 1 (2018): Jurnal Farmasi Galenika Volume 5 No. 1, 2018

Section

Artikel

Citation Check

License

Authors who publish in Jurnal Farmasi Galenika agree to the following terms:

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. CC BY includes the following elements:

Creative Commons License

BY: credit must be given to the creator.

You are free to:

  1. Share — copy and redistribute the material in any medium or format for any purpose, even commercially.
  2. Adapt — remix, transform, and build upon the material for any purpose, even commercially.
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation .

No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.